Table 2.

Parameter values of the computational model

Symbol	Value	Unit	Description	Equation no.	Reference
$E_{\mathit{GPX}}^T$	5.0 × 10−3	mM	Mitochondrial concentration of GPx	1	Cortassa et al., 2004
Φ1	5.0 × 10−3	mM ms	Constant for GPx activity	1	Cortassa et al., 2004
Φ2	0.75	mM ms	Constant for GPx activity	1	Cortassa et al., 2004
$K_M^{\mathit{GSSG}}$	0.06	mM	Km for oxidized GSH of GR	2	Cortassa et al., 2004
$K_M^{\mathit{NADPH}}$	0.015	mM	Km for NADPH of GR	2	Cortassa et al., 2004
$k_{\mathit{GR}}^1$	0.025–0.005	ms−1	Rate constant of GR	2	Cortassa et al., 2004
$E_{\mathit{GR}}^T$	5.0 × 10−3	mM	Mitochondrial concentration of GR	2	Cortassa et al., 2004
GT	3.0	mM	Total mitochondrial pool of GSH	6	Cortassa et al., 2004
$E_{\mathit{PrxX}}^T$	1	mM	Intracellular concentration of Prx	3	Cox et al., 2010
ΦP1	3.83	mM2 ms	Constant for Prx 3 activity	3	Sztajer et al., 2001
ΦP2	0.285	mM2 ms	Constant for Prx 3 activity	3	Sztajer et al., 2001
$K_M^{\mathit{TrxSS}}$	0.05	mM	Km for Trx(SS) of TrxR	4	Pillay et al., 2009; Eckenroth et al., 2006
$K_M^{T-\mathit{NADPH}}$	0.012	mM	Km for NADPH of TrxR	4	Pillay et al., 2009; Eckenroth et al., 2006
$k_{\mathit{TrxR}}^1$	0.022–0.009	ms−1	Rate constant of TrxR	4	Pillay et al., 2009; Eckenroth et al., 2006
$E_{\mathit{TrxR}}^T$	0.025	mM	Mitochondrial concentration of TrxR	4	Pillay et al., 2009
$k_{\mathit{TxPx}}^1$	2.5	mM−1 ms−1	Rate constant of Prx	5	Cox et al., 2010; Adimora et al., 2010
$K_M^{\mathit{Trx}}$	0.1	mM	Km for Trx(SH)2 of Prx	5	Adimora et al., 2010
$K_i^{\mathit{TrxPx}}$	0.01	mM−1	Inhibition constant of Prx activity by Trx(SH)2	5	Adimora et al., 2010
TrxT	0.025	mM	Total mitochondrial pool of Trx	7	Cox et al., 2010
PrxT	0.15	mM	Total mitochondrial pool of Prx	8	Cox et al., 2010
k1	0.1	ms−1	Rate constant of H2O2 transport from mitochondria	9	Adjusteda

^aThis parameter (k₁) was adjusted.