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. 2012 May 29;7(5):e38019. doi: 10.1371/journal.pone.0038019

Table 1. SK-N-SH cell death after OGD depends on RelA-Lys310 acetylation.

Reative LDH release
C OGD15h
pSG5 0,05±0,005 0,27±0,02
RelA 0,04±0,003 0,45±0,04*
RelA-K310R 0,06±0,002 0,13±0,01#
RelA-K310Q 0,04±0,003 0,4 0±0,04*

Data show the cell survival of SK-N-SH cells over-expressing a control vector, pSG5, or wild-type RelA or RelA-K310R or RelA-K310Q constructs and exposed to 15 hours of OGD, compared to controls. Wild-type RelA and RelA-K310Q over-expression significantly enhanced toxicity due to OGD, while RelA-K310R over-expression prevented cell loss. Data are mean±s.e.m of three separate experiments run in triplicate and represent the amount of LDH released by each well, relative to total releasable LDH.

*

p<0,0005 RelA or RelA-K310Q OGD vs relative pSG5;

#

p<0,0005 RelA-K310R OGD vs relative RelA.