Table 1. Functional Annotation Clustering of genes induced 2-fold or greater by IR in wild type (yw) wing imaginal discs (p<0.001).

at 2 hr after irradiation			at 18 hr after irradiation
rank	Enrichment Score	representative terms (GO, INTERPRO, SMART, KEGG_PATHWAY)	rank	Enrichment Score	representative terms (GO, INTERPRO, SMART, KEGG_PATHWAY)
1	5.95	celular response to stress, response to DNA damage stimulus, DNA repair	1	3.09	celular response to stress, response to DNA damage stimulus, DNA repair
2	2.97	NHEJ, DSB repair, telomere maintenance	2	2.77	CHk, CHK kinase-like
3	2.78	positive regulation of cell death, programmed cell death, apoptosis, autophagic cell death	3	2.17	actin cytoskeleton, actomyosin structure organization, cytoskeletal protein binding
4	2.17	co-factor biosynthetic process, co-enzyme biosynthetic process, oxidoreduction coenzyme metabolic process	4	2.17	glutathione transferase activity, drug metabolism, glutathione metabolism
5	2.17	adenyl nucleotide binding, purine nucleotide binding, ATPase activity	5	1.97	contactile fibre part, myosin II complex, actin cytoskeleton
6	1.95	ABC transporter-like, multidrug transporter activity	6	1.90	co-factor biosynthetic process, co-enzyme biosynthetic process
7	1.89	extra-cellular matrix	7	1.88	cell-adhesion
8	1.81	DEAD-like helicase, DNA/RNA helicase	8	1.79	ABC transporter-like, multidrug transporter activity
9	1.80	glutathione transferase activity, drug metabolism, glutathione metabolism	9	1.49	positive regulation of cell death, programmed cell death, apoptosis, autophagic cell death
10	1.71	salivary gland development, hemopoiesis, immune system development	10	1.39	extra-cellular matrix; metallopeptidase activity
11	1.68	larval development, apical part of cell
12	1.55	apical cortex, asymmetric protein localization, cell fate commitment
13	1.49	nucleotidyltransferase, DNA polymerase activity
14	1.45	proteolysis, protease, peptidase activity, endopeptidase activity, hydrolase
15	1.43	positive regulation of caspase activity, positive regulation of peptidase activity, regulation of endopeptidase activity
16	1.33	JNK cascade, stress activated kinase signaling pathway, MAPKKK cascade, embryonic morphogenesis

Only clusters with Enrichment Score of >1.3 are shown. Gene ontology information is from DAVID Bioinformatics Resources 6.7, NIAID/NIH (ttp://david.abcc.ncifcrf.gov/). Clusters present in both 2 hr and 18 hr time-points are in bold font.