Table 2. Cell death related genes induced by IR in yw (≥1.5-fold, p<0.005).
| other information (Flybase) | gene | fold change (p-value) | |||||
| y2− vs y2+ | y18− vs y18+ | p2− vs p2+ | p18− vs p18+ | p2+ vs p18+ | |||
| 1 | DNA binding, leg morphogenesis | ftz-f1(Ftz interacting protein 1) | 0.5(0.000103) | 1.0(7.5e-007) | 0.7(0.073569) | 0.5(0.000359) | 0.7(0.000122) |
| 2 | predicted DNA binding and mRNA splicing | CG6905(–) | 0.6(0.000086) | 0.5(0.008317) | – | – | – |
| 3 | EGF receptor binding | vn(defective dorsal discs) | 0.7(0.000006) | 0.6(0.000428) | -0.3(0.021632) | – | 0.4(0.001491) |
| 4 | influence processing of Dredd RNA | qkr58E-3(KH domain encompassing protein 1) | 0.7(4.2e-008) | 0.3(0.010044) | 0.6(0.000145) | – | -0.3(0.010807) |
| 5 | germ cell death | wun(wunen) | 0.8(0.000671) | 1.8(1.6e-008) | – | – | – |
| 6 | DNA replication | RnrL(ribonucleoside-diphosphate reductase large subunit) | 1.0(2.4e-012) | 0.8(4.10e-08) | – | 0.6(0.000003) | 0.6(0.000005) |
| 7 | pro-apoptotic (predicted) | CG5059(–) | 1.0(2.0e-011) | 1.3(6.1e-012) | -0.5(0.003960) | – | 0.5(0.000213) |
| 8 | aka ‘Dark’; pro-apoptotic | Ark(Apaf-1 related killer) | 1.1(9.3e-009) | 0.6(0.000424) | – | 0.3(0.049208) | 0.4(0.009484) |
| 9 | RNA interference, cell death | AGO2(Argonaute 2) | 1.3(1.2e-011) | 0.8(1.7e-008) | – | – | – |
| 10 | aka ‘Dronc’; pro-apoptotic | Nc(Nedd2-like caspase) | 1.6(4.6e-011) | 0.9(2.0e-007) | – | 0.3(0.019869) | – |
| 11 | pro-apoptotic | p53(p53-like regulator of apoptosis and cell cycle) | 1.7(3.4e-013) | 1.4(5.4e-009) | – | – | – |
| 12 | predicted VEGF receptor binding | Pvf2(VEGF-related factor 2) | 1.9(2.3e-013) | 2.2(6.1e-011) | – | 0.4(0.003801) | 0.4(0.001485) |
| 13 | predicted inhibitor of apoptosis | CG7188(–) | 2.0(8.6e-009) | 1.2(1.6e-010) | 0.3(0.036872) | – | – |
| 14 | JNK signaling | puc(puckered) | 2.2(3.2e-014) | 1.2(2.0e-008) | – | 0.3(0.040766) | 0.6(0.000583) |
| 15 | autophagic cell death | Mmp1(Matrix metalloproteinase1) | 2.5(2.6e-012) | 3.6(0) | −0.4(0.023325) | 0.5(0.000006) | 0.9(8.8e-008) |
| 16 | pro-apoptotic | skl(sickle) | 2.6(2.2e-007) | – | – | 0.2(0.006202) | 0.2(0.006266) |
| 17 | pro-apoptotic | W(hid/W) | 2.8(0) | 1.4(1.1e-010) | -0.7(0.000616) | – | 0.7(0.000014) |
| 18 | pro-apoptotic | rpr(reaper) | 3.1(0) | 1.5(6.8e-010) | 0.5(0.002109) | 0.5(0.001486) | 0.4(0.011275) |
| 19 | JNK signaling | Traf4(TNF Receptor Associated Factor1) | 4.0(0) | 2.4(5.2e-012) | – | 1.0(0.000003) | 0.7(0.000104) |
| 20 | JNK signaling | egr(Eiger) | 5.8(0) | 3.7(3.0e-013) | 0.3(0.034627) | 1.3(0.000399) | 0.7(0.012767) |
| 21 | autophagic cell death | LysS(Lysozyme S) | 5.6(2.4e-010) | −3.3(0.000003) | 2.6(0.001140) | −0.8(0.010742) | −2.8(0.000433) |
| 22 | pro-apoptotic | Corp(Companion of reaper) | 6.2(0) | 5.0(1.1e-015) | – | 0.7(0.015186) | 0.7(0.010899) |
The values shown are log2. The cut-off values were 1.5 fold or more (log2 of 0.585 or greater) with p<0.005 compared to un-irradiated controls, at 2 hr or 18 hr after irradiation or both. ‘–’ = the gene was not significantly induced with respect to neither p-value or fold change. p-value of 0 means p<1e-10. y = yw control; p = p53 mutants, ‘−’ = −IR (0 R); ‘+’ = +IR (4000 R); 2 = 2 hr after irradiation, 18 = 18 hr after irradiation. If there is data for more than one probe set is available for a gene, the set with the best p value was considered.