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. 2012 May 29;7(5):e37629. doi: 10.1371/journal.pone.0037629

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Huang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — (A) Simultaneous openings of pairs and triples of channels in inside-out patch from cardiac myocytes treated with the ischaemic metabolite lysophosphatidylchloline [2]. In the left panel, zero corresponds to closed state; dotted lines and numbers 1,2,3 indicate openings to single, double and triple unitary conductance levels. Right panel shows histogram of current amplitude distribution. Note frequent occurrence of openings to double and triple unitary levels, but no openings to the unitary level. (B) Coopled gating of ryanodine R2 channels in cardiac cells [6]. Left panel shows example traces with openings to single, double and triple unitary conductance levels. Closed state is indicated by c; single, double and triple unitary conductance levels are indicated by 1,2,3. Right panel shows current amplitude histograms, corresponding to the traces on the left. Reproduced with permision from [2] and [6].

Inline graphic — (A) Simultaneous openings of pairs and triples of channels in inside-out patch from cardiac myocytes treated with the ischaemic metabolite lysophosphatidylchloline [2]. In the left panel, zero corresponds to closed state; dotted lines and numbers 1,2,3 indicate openings to single, double and triple unitary conductance levels. Right panel shows histogram of current amplitude distribution. Note frequent occurrence of openings to double and triple unitary levels, but no openings to the unitary level. (B) Coopled gating of ryanodine R2 channels in cardiac cells [6]. Left panel shows example traces with openings to single, double and triple unitary conductance levels. Closed state is indicated by c; single, double and triple unitary conductance levels are indicated by 1,2,3. Right panel shows current amplitude histograms, corresponding to the traces on the left. Reproduced with permision from [2] and [6].