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. 2012 May 29;7(5):e37582. doi: 10.1371/journal.pone.0037582

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(A) The effect of CPA on the change in LCR period predicts the concurrent prolongation of AP cycle length. Note that this effect of CPA on LCR period and AP cycle length form a continuum with the effects of Ru360 and CGP-37157 on LCR period and AP cycle length. (B) In the presence of CPA neither Ru360 nor CGP-37157 affect the LCR period or AP cycle length, and [Ca²⁺]_m decreased. The combination of Ru360 plus CGP-37157 does not change [Ca²⁺]_m, AP cycle length or the LCR period.