Serum albumin (a), total protein (b), and fibrinogen (c) concentrations, and urine protein excretion (d) pre- and post-unilateral and bilateral nephrectomy. Horizontal Lower reference ranges for serum tgroupalbumin and total protein (31 and 61 g/l, respectively), upper range for fibrinogen (4.0 g/L), and definition of nephrotic range proteinuria (40 mg/m2/h). Analyses were performed with Wilcoxon signed-rank test. In cases of sequential nephrectomies, an asterisk indicates measurements before/after the first (unilateral) and before/after the second procedure (bilateral nephrectomy). Note that the majority of patients undergoing unilateral nephrectomy had large proteinuria, but also polyuria or other risk factors leading to kidney removal