Table 2.
Statistically significant biological processes, associated to the upregulated genes only, represented by DE GO terms in our cohort of glioma samples.
| Biological processes | GO terms | Representative genes | Fold change |
|---|---|---|---|
| Immune/inflammatory response | GO:0006955 ∼ immune response | C1QA | 2.25 |
| GO:0009611 ∼ response to wounding | ANXA1 | 3.61 | |
| GO:0006952 ∼ defense response | ANXA5 | 2.99 | |
| GO:0006954 ∼ inflammatory response | CTGF | 6.20 | |
| GO:0019882 ∼ antigen processing and presentation | CD163 | 3.12 | |
| GO:0042060 ∼ wound healing | NOTCH2 | 2.21 | |
| GO:0048002 ∼ antigen processing and presentation of peptide antigen | CD44 | 3.13 | |
| GO:0010033 ∼ response to organic substance | STAT1 | 2.78 | |
| GO:0002684 ∼ positive regulation of immune system process | MYC | 2.75 | |
| GO:0046649 ∼ lymphocyte activation | COL1A1 | 6.72 | |
| GO:0002460 ∼ adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | IFI30 | 4.69 | |
| GO:0002250 ∼ adaptive immune response | CDKN1A | 2.26 | |
| GO:0042110 ∼ T cell activation | CDKN2A | 2.91 | |
| GO:0045321 ∼ leukocyte activation | ERBB2 | 2.48 | |
| GO:0002504 ∼ antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | HBEGF | 3.13 | |
| GO:0045087 ∼ innate immune response | FN1 | 4.86 | |
| GO:0002694 ∼ regulation of leukocyte activation | |||
| GO:0002252 ∼ immune effector process | |||
| GO:0050778 ∼ positive regulation of immune response | |||
| GO:0051249 ∼ regulation of lymphocyte activation | |||
| GO:0006968 ∼ cellular defense response | |||
| GO:0002449 ∼ lymphocyte mediated immunity | |||
| Cell proliferation and survival | GO:0043067 ∼ regulation of programmed cell death | KCNMA1 (variant 2) | 2.53 |
| GO:0042127 ∼ regulation of cell proliferation | ANXA5 | 2.99 | |
| GO:0010941 ∼ regulation of cell death | ANXA1 | 3.61 | |
| GO:0042981 ∼ regulation of apoptosis | MMP9 | 6.35 | |
| GO:0043065 ∼ positive regulation of apoptosis | CD44 | 3.13 | |
| GO:0043068 ∼ positive regulation of programmed cell death | NOTCH2 | 2.21 | |
| GO:0010942 ∼ positive regulation of cell death | IFI30 | 4.69 | |
| GO:0006917 ∼ induction of apoptosis | STAT1 | 2.78 | |
| GO:0012502 ∼ induction of programmed cell death | MYC | 2.75 | |
| GO:0008285 ∼ negative regulation of cell proliferation | CDKN1A | 2.26 | |
| GO:0006915 ∼ apoptosis | CDKN2A | 2.91 | |
| GO:0008219 ∼ cell death | ERBB2 | 2.48 | |
| GO:0008284 ∼ positive regulation of cell proliferation | HBEGF | 3.13 | |
| GO:0016265 ∼ death | PIM1 | 2.76 | |
| GO:0012501 ∼ programmed cell death | |||
| GO:0043066 ∼ negative regulation of apoptosis | |||
| GO:0006916 ∼ anti-apoptosis | |||
| GO:0043069 ∼ negative regulation of programmed cell death | |||
| GO:0060548 ∼ negative regulation of cell death | |||
| Cellular adhesion and motility | GO:0006928 ∼ cell motion | ANXA1 | 3.61 |
| GO:0016477 ∼ cell migration | CTGF | 6.20 | |
| GO:0051674 ∼ localization of cell | CD44 | 3.13 | |
| GO:0048870 ∼ cell motility | MMP9 | 6.35 | |
| GO:0007155 ∼ cell adhesion | COL1A1 | 6.72 | |
| GO:0022610 ∼ biological adhesion | TGFBI | 6.98 | |
| GO:0030198 ∼ extracellular matrix organization | ANXA2P1 | 4.99 | |
| GO:0051270 ∼ regulation of cell motion | ANXA2 | 5.02 | |
| GO:0030334 ∼ regulation of cell migration | ERBB2 | 2.48 | |
| GO:0006935 ∼ chemotaxis | HBEGF | 3.13 | |
| GO:0042330 ∼ taxis | FN1 | 4.86 | |
| GO:0040012 ∼ regulation of locomotion |
Some representative genes are reported with the relative fold change.