Table 8.
Univariable analyses of relation of UBE2C protein and standard variables to overall survival in 92 women with node-positive breast cancer [183].
| Variable | HR | 95% CI | P |
|---|---|---|---|
| Age | 1.06 | 1.01 to 1.12 | 0.026 |
| Histology (IDC versus others) | 0.48 | 0.18 to 1.27 | 0.139 |
| Histological size (<20 mm versus ≥20 mm) | 2.97 | 0.68 to 12.94 | 0.147 |
| SBR (I versus II versus III) | 3.97 | 1.67 to 9.47 | 0.001 |
| Positive nodes (1 versus 2 versus 3 versus >3) | 1.81 | 1.19 to 274 | 0.005 |
| Estrogen receptor (+versus -) | 0.18 | 0.07 to 0.47 | <0.001 |
| Progesterone receptor (+versus -) | 0.51 | 0.19 to 1.37 | 0.182 |
| IHC Ki-67 (<11% versus ≥11%) | 8.59 | 1.14 to 64.57 | 0.037 |
| IHC UBE2C (<11% versus ≥11%) | 7.14 | 1.64 to 31.11 | 0.009 |
| NPI scores (1 versus 2 versus 3) | 4.48 | 1.74 to 11.52 | 0.002 |
CI: confidence interval; IDC: infiltrating ductal carcinoma; IHC: immunohistochemistry; HR: hazard ratio; NPI: Nottingham Prognostic Index; SBR: Scarff-Bloom-Richardson.