Table 5.
Effect modification by type 2 diabetes on the association between NGFR genotype and the risk of Alzheimer's disease stratified by ApoEε4 status
| NGFR non-variant carriers | NGFR variant carriers | Pinteraction | |||
|---|---|---|---|---|---|
| Case/control | OR | Case/control | OR (95%CI) | ||
| ApoEε4 non-carriers | |||||
| rs2072445 | |||||
| Diabetes | 25/40 | 1.00 | 6/4 | 5.53 (0.53-57.61) | |
| Without diabetes | 104/250 | 1.00 | 20/35 | 1.43 (0.70-2.92) | 0.16 |
| rs2072446 | |||||
| Diabetes | 26/26 | 1.00 | 5/18 | 0.48 (0.12-1.98) | |
| Without diabetes | 89/227 | 1.00 | 35/58 | 2.18 (1.19-4.00) | 0.007* |
| rs734194 | |||||
| Diabetes | 23/23 | 1.00 | 8/21 | 0.28 (0.08-0.98) | |
| Without diabetes | 62/144 | 1.00 | 62/141 | 0.87 (0.52-1.45) | 0.14 |
| rs741072 | |||||
| Diabetes | 8/21 | 1.00 | 23/23 | 2.97 (0.91-9.74) | |
| Without diabetes | 56/113 | 1.00 | 68/172 | 0.85 (0.50-1.43) | 0.04 |
| rs741073 | |||||
| Diabetes | 14/27 | 1.00 | 17/17 | 1.84 (0.57-5.89) | |
| Without diabetes | 71/154 | 1.00 | 53/131 | 0.96 (0.57-1.61) | 0.39 |
| ApoE ε4 carriers | |||||
| rs2072445 | |||||
| Diabetes | 12/5 | 1.00 | 4/1 | NA | |
| Without diabetes | 81/38 | 1.00 | 10/11 | 0.49 (0.16-1.46) | NA |
| rs2072446 | |||||
| Diabetes | 13/4 | 1.00 | 3/2 | NA | |
| Without diabetes | 79/44 | 1.00 | 12/5 | 1.49 (0.36-6.21) | NA |
| rs734194 | |||||
| Diabetes | 7/3 | 1.00 | 9/3 | 2.55 (0.20-33.18) | |
| Without diabetes | 52/25 | 1.00 | 39/24 | 0.63 (0.28-1.46) | 0.69 |
| rs741072 | |||||
| Diabetes | 11/4 | 1.00 | 5/2 | 2.09 (0.15-29.98) | |
| Without diabetes | 35/19 | 1.00 | 56/30 | 1.13 (0.47-2.69) | 0.93 |
| rs741073 | |||||
| Diabetes | 8/5 | 1.00 | 8/1 | NA | |
| Without diabetes | 51/31 | 1.00 | 40/18 | 1.24 (0.54-2.86) | NA |
All models were adjusted for age, sex, and education.
Abbreviations: OR, odds ratio; CI, confidence interval; NA, not applicable.
*Result remained significant after controlling for FDR.