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. 2012 May 30;6:77. doi: 10.3389/fnins.2012.00077

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Copyright © 2012 Zou and Crews.

This is an openaccess article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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Ethanol induction of inflammasomes in HEC slices. RT-PCR analysis shows that ethanol exposure persistently up-regulates inflammasome NALP1 mRNA (bar graph, top). Representative confocal images are shown for cellular expression of inflammasome NALP1 and NALP3. (A,B) Double fluorescent immunostaining with NALP1 (red) and neuronal cell marker NeuN (green) show ethanol induction of NALP1 in DG granule neurons (arrows) [(A) control; (B) ethanol, original magnification 20×; insert-80×]. (C,D) Double fluorescent immunostaining with NALP1 (red) and astrocyte neuronal marker GFAP (green) show ethanol induced strong induction of NALP1 in astrocytes (yellow, arrows) [(C) control; (D) ethanol, original magnification 20×; insert-80×]. (E,F) Double fluorescent immunostaining with NALP3 (green) and astrocyte marker GFAP (red) show ethanol induction of inflammasome NALP3 in astrocytes (yellow, arrows) [(E) control; (F) ethanol, original magnification 20×; insert-80×].