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Effects of PEDF on different types of stem cells.
| Stem cell type | PEDF effect | Reference |
|---|---|---|
| Human embryonic stem cell | Proliferation, support, and survival | [22, 23] |
|
| ||
| Neural stem cell | Self-renewal | [31–33] |
| Maintenance of multipotency | ||
| Activation of cell division | ||
| Antiapoptotic effects | ||
|
| ||
| Retinal stem cell | Self-renewal | [35, 37, 38] |
| Cell expansion | ||
| Inhibits migration of and induces apoptosis of endothelial cells | ||
| Regression of CNV (at low doses) | ||
| Development of neovascularisation (at high doses) | ||
