Fig. 1.

A, the different adducts created by cisplatin, oxaliplatin, satraplatin, and picoplatin are illustrated. B, dose-response relationships between platinum analogs and growth inhibition. HeLa cells were treated with different doses of platinating agent for 1 h, washed, and then cultured for 4 days. The number of cells present was counted and normalized to the number of cells present when grown in the absence of drug. Results shown are the mean ± S.E.M. of at least four independent experiments.