Fig. 6.

Molecular models of (S)-CGP-12177 interacting with an inactive model of β₂-AR (PDB code 2RH1, β₂-AR-In) (A) and (R,R′)-MFen interacting with an active model of β₂-AR (PDB code 3POG, β₂-AR-Ac) obtained during docking simulations (B). For clarity of both figures, TM1, TM2, and extracellular loop 2 were hidden, and the remaining transmembrane segments are color coded as follows: TM3, red; TM4, green; TM5, magenta; TM6, yellow; and TM7, blue. Only the residues forming hydrogen bonds (shown as green arrows) with a ligand molecule are shown explicitly. All aliphatic hydrogen atoms are hidden.