TABLE 1.

Characteristics of Included Trials

Author	Year	N	Premature Versus Full-Term Infant	Start of Supplementation (After Birth)	Duration of Supplementation, mo	DHA, 22:6, %a		EPA, 20:5, %	AA, 20:4, %	ALA, 18:3 n-3, %	LA, 18:2 n-6, %	Jadad Scale	Contribution
													Total BSID	MDI	PDI
Scott	1998	134	Term	Within a wk	12	DHA	0.23	0.07	0.0	1.90	20.70	5	Y	Y	Y
						DHA + AA	0.12	0	0.43	1.90	21.70
Lucas	1999	309	Term	Within a wk	6	0.32		0.01	0.30	1.40	15.90	5	Y	Y	Y
Birch	2000	56	Term	Within 2 d	4	DHA	0.35	0	0.02	1.54	15.10	5	Y	Y	Y
						DHA + AA	0.36	0	0.72	1.53	14.90
Makrides	2000	68	Term	Within 1 wk	12	0.35		0.10	0.34	1.10	16.70	3	Y	Y	Y
Auestad	2001	404	Term	Within 9 d	12	Egg, DHA	0.14	0	0.45	2.50	22.40	5	Y	Y	Y
						Fish & Fungi DHA	0.13	0.04	0.46	2.40	21
O'Connor	2001	427	Preterm	Within 3 d	14	Fish & Fungi DHA	0.27	0.08	0.43	2.60	16.80	4	Y	Y	Y
						Egg & Fish DHA	0.24	0	0.41	2.50	17.50
Fewtrell	2002	195	Preterm	5 d	1	0.17		0.04	0.31	0.60	12.00	5	Y	Y	Y
Van Wezel	2002	42	Preterm	2–3 wk	8	0.34		NR	0.70	NR	NR	5	Y	Y	Y
Fewtrell	2004	238	Preterm	Discharge or wt 2 kg	9	0.50		0.10	0.04	1.50	12.30	5	Y	Y	Y
Bouwstra	2005	250	Term	After delivery	2	0.30		NR	0.45	NR	NR	5	Y	Y	Y
Clandinin	2005	361	Preterm	Within 10 d	14.5	Algae DH	0.33	0.10	0.65	2.16	18.40	4	Y	Y	Y
						Fish DHA	0.33	0	0.65	2.16	18.40
Fang	2005	28	Preterm	35 weeks PMA	6	0.05		NR	0.10	NR	NR	5	Y	Y	Y

ALA, α-linolinic acid; LA, linoleic acid; MDI, Mental Development Index; NR, not reported; PDI, Psychomotor Development Index.

^aDoses are defined in g/100 g of fatty acids.