Figure 10.

Rotarod motor learning deficits in male Shank3 null mutant mice. Rotarod scores in Cohorts 1, 2, and 3 were evaluated for latency to either fall or to ride the rod around. Results collected using this criterion revealed significant genotype differences in all three cohorts of males. −/− males exhibited significantly shorter latencies to fall off the rotating rod or to ride the rod around, compared with +/+ males (A, C, E). In females, no significant genotypes differences were found in Cohorts 1 and 2 (B, D). In Cohort 3, −/− females exhibited significantly shorter latencies to fall or ride around compared with +/+ females (F). Cohort 3 was also scored with a more stringent criterion, latency to fall only. A nonsignificant trend was found for Cohort 3 −/− males to fall sooner than +/+ males (G). A similar nonsignificant trend was found in Cohort 3 females (H). *p < 0.05 compared with +/+ on each individual trial. Error bars indicate SEM.