Figure 3.

Homosynaptic LTD in adult hippocampus in vivo. (A) Schematic of the stimulation-recording configuration used in anesthetized rats. (B) LTD induced by a single episode of LFS (1 Hz, 900 pulses) is stable for as long as the preparation is viable. In this example, LFS of the ipsilateral Schaffer collaterals produced LTD that was stable for >6.5 hr. Displayed field potentials were evoked by stimulation of the ipsilateral Schaffer collaterals (averages of 10 consecutive sweeps) at times indicated by numerals. Scale bars: 2 mV, 10 ms. Figure modified from ref. 39.