Table 3.
Infusion Reactions Requiring Hospitalization
| Author | Year | Treatment | Grade of Reaction | Incidence of Reactions | Of Patients who had IRs, % whom Required Hospitalization |
|---|---|---|---|---|---|
| Chemotherapy | |||||
| Brandi et al., [63] | 2003 | FOLFOX 4 | All grades | 18% | 10% |
| Ichikawa et al., [18] | 2009 | FOLFOX4 or modified FOLFOX6 | Grade 3-4 | 6% | 16.7% |
| Matsumoto et al., [56] | 2008 | FOLFOX 6 | Grades 1-4 Grades 3-4 | 19.9% 4.5% | 7.7% 20% |
| mAbs | |||||
| Foley et al., [40] | 2010 | Cetuximab | IRs requiring medical intervention | 8.4% | 39.4% |
| George Jr et al., [41] | 2010 | Cetuximab +/- chemotherapy | Grades 2-4 | 27% | 14.3% |
| Saltz et al., [35] | 2004 | Cetuximab | Grade 3-4 | 5.3% | 33% |
| Schwartz et al., [14] | 2008 | cetuximanb, bevacizumab | Grade 3 or higher | Not reported | 22% |