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ICSS thresholds (A) and response latencies (B) (expressed as percent of baseline, mean ± SEM) following s.c. injection of nicotine alone or extract (0 – 0.75 mg/kg). Threshold and latency data from the two rats administered s.c. extract 1.25 mg/kg are also shown. * Significantly different from saline (0 mg/kg), p < 0.05 or 0.01. # Significantly different from nicotine alone at that dose, p < 0.05 or 0.01.
