Figure 6.

Diagram illustrating two generic synaptic arrangements involving dopamine and major dopamine receptor subtypes CD1, D4, and D5 in the synaptic circuitry of the prefrontal cortex. (Left) Direct mode of pyramidal cell modulation; dopamine (DA) afferents (in red) labeled with a dopamine-specific antibody terminate on the distal dendrites (and spines) of a pyramidal cell (black triangles) in the prefrontal cortex; for further details see Goldman-Rakic et al. (60). vta, Ventral tagmental area (where dopamine cell bodies reside). (Right) Indirect mode of pyramidal cell modulation via dopamine modulation of GABAergic interneurons (blue circle) (81).