Figure 2.

CrtM crystallographic structures. (a) Compound 7 (cyan) plus FMP (yellow) electron density, bound to CrtM. (b) Compound 7 (cyan) bound to CrtM, superimposed on two FSPP molecules (yellow, green; PDB ID code 2ZCP). Also shown is the FMP (magenta) that cocrystallized. The Mg²⁺ are from the FSPP structure. (c) Comparison between 7 (cyan) and 3 (magenta, PDB ID code 2ZCQ) bound to CrtM. Both diphenyl ether side chains bind in S1. (d) Interactions between 7 (cyan), FMP (magenta), and Mg²⁺ in CrtM.