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UPPS crystallographic structures. (a) Electron density of 9 bound to UPPS. (b) Structure of 9 (cyan) bound to UPPS, superimposed on FSPP/Mg2+ (from PDB ID code 1X06) and four bisphosphonate inhibitors (PDB ID code 2E98). (c) Superposition of 9 (cyan) on FSPP (yellow) in site 1 in UPPS. The Mg2+ is from the FSPP structure. (d) The diketo-acid headgroup of 9 binds into the active site of UPPS and interacts with D26 and N28.
