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AT8 staining for phosphorylated mouse tau in the brains of CVND-AD mice treated with COG1410 is visually reduced compared to LRB vehicle. a, c Treated with LRB. b, d Treated with COG1410. Treatments were by subcutaneous injection 3 times per week for months 9, 10 and 11, followed by perfusion, fixation in 4% paraformaldehyde, cutting of frozen sections and staining of free-floating sections with AT8. Representative pictures from individual mice are shown.
