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Oligomeric species (anti-oligomer antibody, A11) accumulate in ER. CAD cells were transfected with HA-KLC-TPR. This construct expresses the 6 TPRs of KLC, which can simultaneously bind 2 proteins. Insets are magnifications of the cell in the lower, left corner of the images. The graph shows direct correlation between the levels of oligomers and expressed HA-KLC-TPR. Bars = 20 μm.
