Figure 3.

The effects of YGW on Der-p-induced airway inflammation, goblet cell hyperplasia, mucus hypersecretion, and collagen deposition in lung tissue of mice. Airway hyperresponsiveness was determined three days after the last challenge. Histopathologic studies of inflammatory cells around the blood vessels (H&E stain; original magnification, ×400) (a) and activity of goblet cells (PAS; original magnification, ×400) in airway epithelial cells (b). Degrees of airway inflammation and goblet cell hyperplasia were estimated as described in Section 2. (c) Collagen levels in lung tissue were significantly higher in the Der p group. Values represent the means ± SD of 6 mice. *P < 0.05 (versus naïve group); ^# P < 0.05 (between nontreated and YGW-treated groups). Values represent the means ± SD of 6 mice.