Table 3.
Interpretation of MPTP mass spectrometry, assuming spontaneous generation of-H2 (to MPDP+) and-2H2 (to MPP+) analogs during fragmentation. MPP+ fragments in column A were listed as a starting point, and m/z values were seen in the MPTP product ion spectrum. Plus 2 (column B) and plus 4 (column C) analogs of MPP+ are also listed with projected hypothetical fragments arising from simple +2 or +4 calculations, and all of the m/z values listed were observed in MPTP fragmentation. Some unseen fragments are also shown in parentheses for continuity, and some additional fragments differing due to migration of a single proton are listed in columns labeled A−1, B−1, C−1, and C+1.
| A−1 | A
|
B–1 or A+1 | B
|
C–1 or B+1 | C
|
C+1 | Interpretation |
|---|---|---|---|---|---|---|---|
| MPP+ C12 H12 N1 | MPDP+ C12 H14 N1 | MPTP+H C12 H16 N1 | |||||
| 170 | 172 | 174 | Molecular ion | ||||
| (154) | 156 | 157 | 158 | 159 | Loss of CH4 | ||
| 144 | 145 | 146 | (147) | Loss of HC=CH or analog | |||
| 128 | 130 | 131 | (132) | Loss of CH3NHCH3 or analog | |||
| 115 | 117 | 118 | (119) | C6H5C=C=CH2+ or analog | |||
| 103 | (104) | 105 | 106 | C6H5C=CH2+ or analog | |||
| 91 | (92) | (94) | 96 | Loss of C6H6 ring or analog | |||
| 77 | 79 | Pyridinyl ring C5H3N+ or analog | |||||
| 68 | CH3NH(CH)C=CH+ or analog | ||||||
| 58 | CH3NHCH2CH2+ or analog | ||||||
| (51) | (53) | 55 | CH3NHC=CH+ or analog | ||||
| 42 | 44 | CH3NHCH2+ or analog |