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Remote memory in the passive avoidance assay is impaired in ERK5 icKO mice. Mice were trained with one 0.7 mA, 2 s footshock in the passive avoidance assay. A, Schematic illustration of the experimental design. B, Crossover latency was measured 24 h or 21 d after training. Data represent mean ± SEM with n ≥ 10 per treatment group. n.s., Not significant. ***p < 0.001.
