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. 2012 May 9;32(19):6444–6455. doi: 10.1523/JNEUROSCI.6076-11.2012

Figure 3.

Figure 3.

ERK5-positive cells along the SGZ are significantly reduced 3 and 12 weeks after tamoxifen treatment. A–F, ERK5 immunostaining 3 weeks after a 7 d treatment paradigm with vehicle control (A–C, Control) or tamoxifen (D–F, icKO). G–L, ERK5 immunostaining 12 weeks after a 3 × 4 d treatment paradigm with vehicle control (G–I, Control) or tamoxifen (J–L, icKO). Scale bar, 25 μm. Dashed lines outline the SGZ layer of the dentate gyrus. M, Quantification of total ERK5-positive cells per dentate gyrus. Data represent mean percentage from two independent experiments; error bars represent SEM with n ≥ 2 animals per treatment group per time point per experiment. **p < 0.01.