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Effect of a perturbation on a dynamically regulating model neuron. The neuron was initially active in bursts. At the arrowhead, the extracellular K+ concentration in the simulation was increased. The neuron initially depolarized but over time regulated its conductances to return to its initial activity patterns. [Reprinted with permission from LeMasson, G., Marder, E. & Abbott, L. F. (1993) Science 259, 1915–1917] Copyright (1993). American Association for the Advancement of Science.
