. Author manuscript; available in PMC: 2012 May 30.

Published in final edited form as: FEBS Lett. 2010 Oct 20;584(24):4923–4932. doi: 10.1016/j.febslet.2010.10.018

Table 1.

Hem family orthologues, expression patterns, and null allele phenotypes.

Species	Hem family (% homology relative to hHem1)^b	Expression^a	Associated proteins	Hem null allele	References
Drosophila melanogaster	Kette (47%)	Embryonic tissue, head	Sra-1, Scar, Abi, HSPC300	Impaired actin cytoskeleton, defective axon projections	[44,51,52]
Caenorhabditis elegans	GEX-3 (36%)	Embryo, L1/L2 larva stages	GEX1, GEX-2, Abi-1	Impaired morphogenesis and cell migration	[53]
Dictyostelium discoideum	Nap1 (24%)	Ubiquitous	PIR121, Scar, Abl-interactor homolog, Brick1	Impaired actin polymerization, small pseudopods, decreased adhesion and multicellular development	[54]
Arabidopsis thaliana	Nap1 (22%)	Flower, root, seed, silique	Klunker, Scar2, BRK1	Disrupted F-actin polymerization and trichome morphology	[55]
Mammals	Hem1 [NCKAP1L (NAP1-like)]	Hematopoietic cells	Abi1/2, PIR121, HSPC300, WAVE1/2, Myosin IXB, Vps34, RhoGAP4, catalytic subunit of myosin light chain phosphatase	Impaired actin polymerization, phagocytosis, migration in neutrophils; impaired T cell development, activation, adhesion; impaired B cell development; regenerative anemia; increased HSC/Ps in peripheral blood	[10,43]
Homo sapiens	− hHem1 (100%)
Mus musculus	− mHem1 (94%)
	Hem2 [NCKAP1(NAP1)]	Ubiquitous	Abi1/2, PIR121, HSPC300, WAVE1/2	Mid-gestation embryonic lethal; failed neural tube closure, impaired neuronal differentiation	[59,60]
Homo sapiens	− hHem2 (58%)
Mus musculus	− mHem2 (58%)

Gene expression is based on NCBI UniGene website and the listed references.

% homology based on amino acids.