Table 1.
Species | Hem family (% homology relative to hHem1)b | Expressiona | Associated proteins | Hem null allele | References |
---|---|---|---|---|---|
Drosophila melanogaster | Kette (47%) | Embryonic tissue, head | Sra-1, Scar, Abi, HSPC300 | Impaired actin cytoskeleton, defective axon projections | [44,51,52] |
Caenorhabditis elegans | GEX-3 (36%) | Embryo, L1/L2 larva stages | GEX1, GEX-2, Abi-1 | Impaired morphogenesis and cell migration | [53] |
Dictyostelium discoideum | Nap1 (24%) | Ubiquitous | PIR121, Scar, Abl-interactor homolog, Brick1 | Impaired actin polymerization, small pseudopods, decreased adhesion and multicellular development | [54] |
Arabidopsis thaliana | Nap1 (22%) | Flower, root, seed, silique | Klunker, Scar2, BRK1 | Disrupted F-actin polymerization and trichome morphology | [55] |
Mammals |
Hem1 [NCKAP1L (NAP1-like)] |
Hematopoietic cells | Abi1/2, PIR121, HSPC300, WAVE1/2, Myosin IXB, Vps34, RhoGAP4, catalytic subunit of myosin light chain phosphatase | Impaired actin polymerization, phagocytosis, migration in neutrophils; impaired T cell development, activation, adhesion; impaired B cell development; regenerative anemia; increased HSC/Ps in peripheral blood | [10,43] |
Homo sapiens | − hHem1 (100%) | ||||
Mus musculus | − mHem1 (94%) | ||||
Hem2 [NCKAP1(NAP1)] |
Ubiquitous | Abi1/2, PIR121, HSPC300, WAVE1/2 | Mid-gestation embryonic lethal; failed neural tube closure, impaired neuronal differentiation | [59,60] | |
Homo sapiens | − hHem2 (58%) | ||||
Mus musculus | − mHem2 (58%) |
Gene expression is based on NCBI UniGene website and the listed references.
% homology based on amino acids.