Table 1.

SPR binding data for α-peptide 5 and α/β-peptides 6, 7, 2c, and 4c

IC50 (nm) [SPR]a
Peptide	Bcl-xL	Bcl-2	Bcl-w	Mcl-1
5	13 ± 4	4.1 ± 0.5	9 ± 0.5	1.1 ± 0.2
6	34 ± 6	96 ± 1	41 ± 13	1.7 ± 0.2
7	7.5 ± 2	5.2 ± 1	7.5 ± 0.5	2.4 ± 0.3
2c	1005 ± 25	4890 ± 370	620 ± 35	70 ± 7
4c	21 ± 1	107 ± 8	29 ± 2	109 ± 1

^aRelative binding of α- and α/β-peptides to pro-survival proteins determined by competition assays using a Biacore instrument.