Table 2.
MIC90 values of conjugate 13 and ciprofloxacin against ESKAPEE panel of bacteria.
| MIC90(M) Against ESKAPEE Test Organismsa, b | |||||||
|---|---|---|---|---|---|---|---|
| Compds |
E. faecium |
S. aureus |
K. pneunonia |
A. baumanii |
P. aeruginosa |
E. aerogenes |
E. coli |
| NCTC 7171 |
ATCC 29213 |
ATCC 700603 |
ATCC 17961 |
ATCC 27853 |
ATCC 35029 |
ATCC 25922 |
|
| 13 | >128 | 32 | 16 | 8 | 8 | 1 | 1 |
| Ciprofloxacin | 8 | NT | 0.25 | 0.25 | 0.25 | <0.015 | <0.015 |
a
MIC90 values (µM) were determined using the broth microdilution method in Mueller-Hinton broth No.2 (MHII) with visual end point analysis according to the CLSI guidelines. 36
b
Each compound was tested in triplicate.
NT, not tested.