Figure 6. Respiration of isolated subsarcolemmal mitochondria (SSM) in 24 hour ACF and the effects of allopurinol.
State 2 and 4 SSM respiration did not differ among all groups. State 3 SSM respiration, a reflection of the mitochondria’s maximal ability to consume oxygen, was decreased in ACF vs. shams and significantly improved in ACF + allopurionol, suggesting XO-mediated bioenergetic dysfunction in ACF. n=6 per group.