Table 4. Multivariable analysis of clinico-pathological parameters for the prognosis of cancer-specific survival in patients with KRAS wild-type colorectal cancer.
|
Cancer-specific survival
|
||
|---|---|---|
| Parameter | HR (95% CI) | P -value |
| Age at diagnosis (years) | ||
| <60 | 1 (Reference) | 0.859 |
| ⩾60 | 1.05 (0.61–1.81) | |
| Tumour grade | ||
| G1+G2 | 1 (Reference) | 0.003 |
| G3 | 2.47 (1.36–4.51) | |
| Tumour stage | ||
| II+III | 1 (Reference) | |
| IV | 1.38 (0.78–2.46) | 0.270 |
| Level of CEA | ||
| Normal | 1 (Reference) | 0.023 |
| Increased | 1.92 (1.09–3.37) | |
| miRNA-143 expression | ||
| High | 1 (Reference) | 0.031 |
| Low | 1.86 (1.06–3.25) | |
Abbreviations: CEA=carcinoembryonic antigen; CI=confidence interval; HR=hazard ratio; miRNA=microRNA.