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. 2012 May 30;7(5):e38030. doi: 10.1371/journal.pone.0038030

Figure 1. Inhibition of Ca2+-activated Cl− channels by a Thai herbal formulation.

Figure 1

A. Thai herbal medicine for diarrhea. B. Short-circuit measurement in T84 cells. Representative current trace (dark curve) shows inhibition of ATP (100 µM)-stimulated native CaCC Cl− current by the Thai herbal formulation. Current in the control study (gray curve) without the herbal formulation was inhibited with 100 µM tannic acid. C. Current measurement in TMEM16A-transfected FRT cells shows inhibition of Eact (10 µM, a TMEM16A activator)-stimulated TMEM16A Cl− current by the Thai herbal formulation (dark curve). Control study (gray curve) without the herbal formulation shows that 10 µM T16Ainh-A01 (TMEM16A-selective inhibitor) totally inhibited the current.