Table 2. Virus shedding in stools following experimental inoculation.

	Rhesus	Virus	Virus	Duration of	Maximum Shedding
N	Macaque	Inoculum	Shed in Stools	Shedding [Days]	[RNA copies per gram of stools / day]
1	HC55	TV (GI.1)	TV (GI.1)	8	113,000 (day 2)
2	HI77	TV (GI.1)	TV (GI.1)	9	10,600 (day 3)
3	HB61	TV (GI.1)	TV (GI.1)	10	273,300 (day 3)
4	HB11	NoV (GII.2 & GII.4)	NoV (GII.2 & GII.4)	13	76,400 (day 9)
5	GI96	NoV (GII.2 & GII.4)	NoV (GII.2)	4	NAa

Virus shedding for the TV-inoculated animals started on day 1 (HC55 and HI77) and on day 2 (HB61). For the NoV-inoculated animals virus shedding started on day 1 (HB11) and day 2 (GI96) as determined by nested RT-PCR. No samples from GI96 were however positive by qRT-PCR and only samples corresponding to HB11 days 1, 2 and 9 were positive and quantitatively evaluated. Considering that juvenile rhesus macaques of 2.5–4.0 years of age produce daily 80±20 grams of stool, the three TV-inoculated and HB11 macaques produced more virus in stools than what they received in inoculum. ^anot applicable.