Table 3. Individual and Combined analysis of 54 SNPs in CARE, WOSCOPS, and PROSPER/PHASE.
| Combined Analysis | CARE | WOSCOPS | PROSPER | |||||||
| SNP | LD SNP | r2 | SI (95%CI) | P value | SI (95%CI) | P value | SI (95%CI) | P value | SI (95%CI) | P value |
| rs13279522 | 0.63 (0.52 – 0.75) | 4.84E-07 | 0.63 (0.47 – 0.84) | 1.87E-03 | 0.63 (0.44 – 0.90) | 1.12E-02 | 0.62 (0.46 – 0.84) | 2.39E-03 | ||
| rs3732788 | 0.61 (0.48 – 0.77) | 3.95E-05 | 0.55 (0.37 – 0.82) | 2.80E-03 | 0.54 (0.33 – 0.87) | 1.08E-02 | 0.72 (0.49 – 1.07) | 1.02E-01 | ||
| rs13318232 | 0.62 (0.49 – 0.78) | 5.66E-05 | 0.61 (0.42 – 0.89) | 1.11E-02 | 0.49 (0.30 – 0.79) | 3.19E-03 | 0.72 (0.49 – 1.07) | 1.03E-01 | ||
| rs1538185 | 1.41 (1.19 – 1.67) | 6.58E-05 | 1.61 (1.22 – 2.12) | 7.00E-04 | 1.26 (0.90 – 1.75) | 1.77E-01 | 1.33 (1.01 – 1.75) | 4.22E-02 | ||
| rs16861476 | rs3732788 | CW, 1 | 0.62 (0.49 – 0.79) | 9.61E-05 | 0.55 (0.37 – 0.82) | 2.80E-03 | 0.54 (0.33 – 0.87) | 1.08E-02 | 0.77 (0.52 – 1.15) | 2.00E-01 |
| rs9859901 | 0.63 (0.49 – 0.80) | 1.17E-04 | 0.59 (0.40 – 0.87) | 6.91E-03 | 0.50 (0.31 – 0.82) | 5.37E-03 | 0.77 (0.52 – 1.14) | 1.90E-01 | ||
| rs2505039 | 0.77 (0.67 – 0.88) | 1.21E-04 | 0.69 (0.56 – 0.86) | 8.36E-04 | 0.78 (0.60 – 1.02) | 6.83E-02 | 0.85 (0.68 – 1.06) | 1.53E-01 | ||
| rs10155047 | 0.62 (0.49 – 0.79) | 1.26E-04 | 0.59 (0.40 – 0.86) | 6.05E-03 | 0.50 (0.31 – 0.80) | 4.45E-03 | 0.77 (0.52 – 1.14) | 1.90E-01 | ||
| rs13314266 | 0.61 (0.47 – 0.79) | 1.45E-04 | 0.63 (0.41 – 0.94) | 2.58E-02 | 0.46 (0.28 – 0.77) | 3.08E-03 | 0.71 (0.46 – 1.10) | 1.25E-01 | ||
| rs9375683 | 1.36 (1.16 – 1.60) | 1.57E-04 | 1.54 (1.18 – 2.00) | 1.37E-03 | 1.25 (0.91 – 1.71) | 1.76E-01 | 1.29 (0.99 – 1.68) | 6.02E-02 | ||
| rs16861467 | 0.60 (0.46 – 0.80) | 4.21E-04 | 0.59 (0.40 – 0.87) | 8.43E-03 | 0.45 (0.27 – 0.73) | 1.46E-03 | 0.76 (0.51 – 1.12) | 1.59E-01 | ||
| rs4682522 | 0.65 (0.51 – 0.83) | 4.47E-04 | 0.63 (0.42 – 0.93) | 2.07E-02 | 0.56 (0.35 – 0.90) | 1.72E-02 | 0.74 (0.50 – 1.10) | 1.42E-01 | ||
| rs6075209† | 0.77 (0.65 – 0.90) | 1.01E-03 | 0.66 (0.53 – 0.83) | 3.42E-04 | 0.83 (0.61 – 1.12) | 2.20E-01 | 0.84 (0.68 – 1.05) | 1.30E-01 | ||
| rs12659030 | 1.28 (1.10 – 1.48) | 1.19E-03 | 1.26 (0.99 – 1.62) | 6.54E-02 | 1.42 (1.07 – 1.87) | 1.38E-02 | 1.19 (0.93 – 1.51) | 1.63E-01 | ||
| rs4626316 | rs7701604 | P, 1 | 0.45 (0.27 – 0.73) | 1.20E-03 | 0.41 (0.22 – 0.74) | 3.13E-03 | 0.47 (0.17 – 1.31) | 1.50E-01 | 0.73 (0.16 – 3.35) | 6.81E-01 |
| rs4242084 | rs2148575 | CW, 1 | 0.50 (0.33 – 0.76) | 1.31E-03 | 0.40 (0.21 – 0.75) | 4.27E-03 | 0.47 (0.19 – 1.20) | 1.15E-01 | 0.70 (0.34 – 1.41) | 3.16E-01 |
| rs10189905 | 0.62 (0.45 – 0.84) | 2.46E-03 | 0.50 (0.34 – 0.74) | 6.25E-04 | 0.56 (0.36 – 0.88) | 1.21E-02 | 0.83 (0.56 – 1.21) | 3.28E-01 | ||
| rs17076974 | 1.29 (1.09 – 1.53) | 2.64E-03 | 1.48 (1.19 – 1.84) | 4.37E-04 | 1.32 (1.02 – 1.71) | 3.48E-02 | 1.12 (0.90 – 1.39) | 3.23E-01 | ||
| rs7705993 | 1.30 (1.09 – 1.56) | 4.13E-03 | 1.52 (1.22 – 1.88) | 1.66E-04 | 1.30 (1.01 – 1.68) | 4.04E-02 | 1.12 (0.90 – 1.39) | 3.13E-01 | ||
| rs3759607† | 1.57 (1.14 – 2.15) | 5.05E-03 | 2.03 (1.31 – 3.14) | 1.46E-03 | 1.54 (0.89 – 2.67) | 1.19E-01 | 1.21 (0.77 – 1.90) | 4.15E-01 | ||
| rs9436636 | 1.21 (1.06 – 1.39) | 5.45E-03 | 1.34 (1.07 – 1.67) | 1.10E-02 | 1.26 (0.97 – 1.63) | 8.28E-02 | 1.07 (0.85 – 1.34) | 5.61E-01 | ||
| rs1544214 | 1.27 (1.07 – 1.50) | 6.01E-03 | 1.41 (1.13 – 1.76) | 2.30E-03 | 1.36 (1.05 – 1.76) | 2.05E-02 | 1.08 (0.87 – 1.35) | 4.83E-01 | ||
| rs2129571 | 0.66 (0.49 – 0.89) | 7.24E-03 | 0.63 (0.43 – 0.92) | 1.65E-02 | 0.50 (0.30 – 0.81) | 5.10E-03 | 0.87 (0.58 – 1.30) | 4.90E-01 | ||
| rs9857† | 0.80 (0.68 – 0.94) | 7.89E-03 | 0.70 (0.54 – 0.90) | 6.34E-03 | 0.81 (0.58 – 1.14) | 2.21E-01 | 0.91 (0.71 – 1.17) | 4.59E-01 | ||
| rs12155847* | 1.31 (1.06 – 1.63) | 1.38E-02 | 1.57 (1.24 – 2.00) | 1.71E-04 | 1.30 (0.95 – 1.79) | 1.06E-01 | 1.11 (0.89 – 1.40) | 3.50E-01 | ||
| rs13137776 | 0.81 (0.67 – 0.97) | 2.32E-02 | 0.73 (0.58 – 0.93) | 9.51E-03 | 0.74 (0.55 – 0.98) | 3.67E-02 | 0.96 (0.76 – 1.22) | 7.58E-01 | ||
| rs10740308 | rs2030057 | CW, 0.95 | 0.73 (0.55 – 0.97) | 2.83E-02 | 0.56 (0.42 – 0.75) | 7.97E-05 | 0.80 (0.57 – 1.12) | 2.02E-01 | 0.88 (0.65 – 1.18) | 3.87E-01 |
| rs7901888 | rs2030057 | CW, 1 | 0.73 (0.55 – 0.97) | 2.83E-02 | 0.56 (0.42 – 0.75) | 7.97E-05 | 0.80 (0.57 – 1.12) | 2.02E-01 | 0.88 (0.65 – 1.18) | 3.87E-01 |
| rs7910196 | 1.25 (1.02 – 1.53) | 3.37E-02 | 1.32 (0.98 – 1.78) | 6.93E-02 | 1.47 (1.05 – 2.05) | 2.63E-02 | 1.03 (0.75 – 1.40) | 8.75E-01 | ||
| rs231358 | rs231355 | CW, 0.96 | 1.20 (1.01 – 1.41) | 3.42E-02 | 1.32 (1.06 – 1.64) | 1.27E-02 | 1.29 (1.00 – 1.66) | 5.06E-02 | 1.02 (0.82 – 1.27) | 8.58E-01 |
| rs9446187 | 1.48 (1.03 – 2.13) | 3.45E-02 | 1.70 (1.17 – 2.46) | 5.24E-03 | 1.92 (1.14 – 3.22) | 1.36E-02 | 1.04 (0.69 – 1.57) | 8.48E-01 | ||
| rs2157673* | 1.32 (1.02 – 1.72) | 3.73E-02 | 1.55 (1.21 – 1.98) | 4.44E-04 | 1.47 (1.08 – 2.01) | 1.53E-02 | 1.04 (0.82 – 1.31) | 7.42E-01 | ||
| rs3793048 | rs3806005 | CW, 1 | 1.49 (1.02 – 2.18) | 3.97E-02 | 1.76 (1.17 – 2.65) | 6.60E-03 | 1.89 (1.12 – 3.19) | 1.65E-02 | 1.04 (0.69 – 1.57) | 8.47E-01 |
| rs10762236 | 0.73 (0.54 – 0.99) | 4.15E-02 | 0.55 (0.42 – 0.73) | 3.02E-05 | 0.84 (0.60 – 1.17) | 2.94E-01 | 0.87 (0.65 – 1.17) | 3.62E-01 | ||
| rs238272 | rs9525613 | CW, 1 | 1.25 (1.01 – 1.56) | 4.24E-02 | 1.35 (1.05 – 1.72) | 1.82E-02 | 1.46 (1.12 – 1.92) | 5.59E-03 | 1.02 (0.81 – 1.29) | 8.65E-01 |
| rs7742508 | 1.55 (1.02 – 2.36) | 4.24E-02 | 1.95 (1.26 – 3.03) | 2.83E-03 | 1.91 (1.09 – 3.35) | 2.45E-02 | 1.05 (0.68 – 1.61) | 8.41E-01 | ||
| rs17716275 | 1.61 (1.01 – 2.56) | 4.53E-02 | 1.81 (1.07 – 3.07) | 2.61E-02 | 2.19 (1.19 – 4.05) | 1.22E-02 | 0.93 (0.45 – 1.90) | 8.32E-01 | ||
| rs7671659 | rs6857038 | P, 0.95 | 1.29 (1.00 – 1.67) | 4.89E-02 | 1.54 (1.17 – 2.02) | 1.89E-03 | 1.38 (0.98 – 1.94) | 6.75E-02 | 1.01 (0.73 – 1.38) | 9.76E-01 |
| rs3998860 | 0.75 (0.56 – 1.00) | 5.22E-02 | 0.57 (0.43 – 0.76) | 8.52E-05 | 0.85 (0.61 – 1.19) | 3.44E-01 | 0.89 (0.67 – 1.19) | 4.27E-01 | ||
| rs1615197* | 1.33 (1.00 – 1.77) | 5.28E-02 | 1.29 (1.04 – 1.60) | 2.23E-02 | 1.82 (1.35 – 2.46) | 9.69E-05 | 1.05 (0.84 – 1.31) | 6.72E-01 | ||
| rs7913568 | rs3998860 | CW, 0.97 | 0.75 (0.56 – 1.01) | 5.75E-02 | 0.57 (0.43 – 0.76) | 8.52E-05 | 0.85 (0.61 – 1.19) | 3.44E-01 | 0.90 (0.67 – 1.21) | 4.85E-01 |
| rs7751843 | rs7765440 | CW, 1 | 1.45 (0.98 – 2.14) | 6.39E-02 | 1.80 (1.25 – 2.59) | 1.66E-03 | 1.74 (1.13 – 2.66) | 1.11E-02 | 0.98 (0.67 – 1.44) | 9.16E-01 |
| rs1917527† | rs12635482 | CW, 0.93 | 0.86 (0.73 – 1.01) | 6.65E-02 | 0.75 (0.60 – 0.94) | 1.08E-02 | 0.86 (0.65 – 1.14) | 2.85E-01 | 0.98 (0.78 – 1.23) | 8.69E-01 |
| rs10831415 | rs10831416 | CW, 1 | 1.21 (0.98 – 1.50) | 8.08E-02 | 1.27 (1.02 – 1.57) | 3.30E-02 | 1.45 (1.12 – 1.87) | 4.84E-03 | 0.99 (0.80 – 1.23) | 9.29E-01 |
| rs7521242 | 0.86 (0.71 – 1.03) | 9.40E-02 | 0.72 (0.58 – 0.90) | 4.10E-03 | 0.89 (0.69 – 1.15) | 3.91E-01 | 0.97 (0.78 – 1.21) | 8.15E-01 | ||
| rs1016030 | rs10831417 | CW, 0.96 | 1.22 (0.97 – 1.53) | 9.66E-02 | 1.25 (1.01 – 1.56) | 4.37E-02 | 1.49 (1.15 – 1.93) | 2.31E-03 | 0.99 (0.79 – 1.23) | 8.93E-01 |
| rs7625204 | 1.28 (0.95 – 1.71) | 1.00E-01 | 1.57 (1.20 – 2.05) | 9.41E-04 | 1.38 (1.02 – 1.87) | 3.67E-02 | 0.97 (0.75 – 1.26) | 8.29E-01 | ||
| rs9807521† | rs977160 | CW, 1 | 1.20 (0.96 – 1.50) | 1.09E-01 | 1.38 (1.07 – 1.78) | 1.32E-02 | 1.31 (0.95 – 1.81) | 9.59E-02 | 0.98 (0.76 – 1.26) | 8.48E-01 |
| rs2281122† | 1.36 (0.92 – 2.00) | 1.25E-01 | 1.32 (0.99 – 1.76) | 5.56E-02 | 2.03 (1.40 – 2.96) | 2.14E-04 | 0.98 (0.75 – 1.28) | 8.86E-01 | ||
| rs1524962† | 0.81 (0.61 – 1.07) | 1.30E-01 | 0.65 (0.50 – 0.84) | 1.07E-03 | 0.78 (0.56 – 1.08) | 1.28E-01 | 1.02 (0.80 – 1.29) | 8.85E-01 | ||
| rs1450092 | 0.80 (0.60 – 1.07) | 1.35E-01 | 0.62 (0.46 – 0.84) | 2.05E-03 | 0.79 (0.57 – 1.11) | 1.74E-01 | 1.02 (0.77 – 1.35) | 8.84E-01 | ||
| rs2335451† | rs10875941 | CWP,1 | 0.77 (0.54 – 1.10) | 1.50E-01 | 0.78 (0.62 – 0.99) | 4.51E-02 | 0.52 (0.36 – 0.75) | 3.99E-04 | 1.05 (0.82 – 1.34) | 7.13E-01 |
| rs10875941† | 0.76 (0.52 – 1.11) | 1.50E-01 | 0.78 (0.62 – 0.99) | 4.51E-02 | 0.50 (0.34 – 0.71) | 1.66E-04 | 1.05 (0.82 – 1.34) | 7.13E-01 | ||
| rs2593270 | rs4765531 | CW, 1 | 0.79 (0.58 – 1.09) | 1.57E-01 | 0.71 (0.55 – 0.92) | 9.77E-03 | 0.64 (0.47 – 0.86) | 2.93E-03 | 1.07 (0.85 – 1.36) | 5.56E-01 |
| rs2656824 | rs4765531 | CW, 1 | 0.79 (0.58 – 1.09) | 1.57E-01 | 0.71 (0.55 – 0.92) | 9.77E-03 | 0.64 (0.47 – 0.86) | 2.93E-03 | 1.07 (0.85 – 1.36) | 5.56E-01 |
| rs2941528* | 0.78 (0.56 – 1.10) | 1.59E-01 | 0.75 (0.58 – 0.97) | 2.68E-02 | 0.58 (0.41 – 0.81) | 1.38E-03 | 1.07 (0.83 – 1.38) | 6.04E-01 | ||
| rs2196180 | rs1560901 | CW, 1 | 1.16 (0.93 – 1.45) | 1.78E-01 | 1.37 (1.07 – 1.76) | 1.33E-02 | 1.23 (0.92 – 1.63) | 1.58E-01 | 0.95 (0.75 – 1.21) | 6.87E-01 |
| rs3861810 | rs1560901 | CW, 1 | 1.16 (0.93 – 1.46) | 1.83E-01 | 1.37 (1.07 – 1.76) | 1.33E-02 | 1.23 (0.92 – 1.63) | 1.58E-01 | 0.95 (0.75 – 1.21) | 6.73E-01 |
| rs2273816* | 1.32 (0.87 – 2.01) | 1.87E-01 | 1.59 (1.16 – 2.18) | 4.20E-03 | 1.69 (1.16 – 2.47) | 6.17E-03 | 0.88 (0.65 – 1.20) | 4.30E-01 | ||
| rs1594887 | rs1529806 | CW, 1 | 1.16 (0.92 – 1.46) | 1.97E-01 | 1.39 (1.09 – 1.79) | 9.01E-03 | 1.20 (0.91 – 1.59) | 2.03E-01 | 0.95 (0.75 – 1.21) | 6.70E-01 |
| rs2060411 | 1.15 (0.92 – 1.44) | 2.27E-01 | 1.33 (1.04 – 1.70) | 2.48E-02 | 1.25 (0.94 – 1.66) | 1.22E-01 | 0.93 (0.73 – 1.18) | 5.45E-01 | ||
| rs7629574† | 0.84 (0.62 – 1.13) | 2.41E-01 | 0.66 (0.51 – 0.84) | 1.02E-03 | 0.84 (0.61 – 1.15) | 2.73E-01 | 1.06 (0.83 – 1.35) | 6.22E-01 | ||
| rs10429616 | 1.20 (0.88 – 1.63) | 2.41E-01 | 1.50 (1.21 – 1.87) | 2.56E-04 | 1.27 (0.97 – 1.65) | 7.95E-02 | 0.91 (0.73 – 1.13) | 4.07E-01 | ||
| rs10778050† | rs4764738 | CW, 0.93 | 1.20 (0.88 – 1.63) | 2.45E-01 | 1.12 (0.90 – 1.39) | 3.09E-01 | 1.70 (1.26 – 2.28) | 4.58E-04 | 0.95 (0.76 – 1.18) | 6.41E-01 |
| rs17138705† | 0.76 (0.47 – 1.22) | 2.51E-01 | 0.54 (0.39 – 0.75) | 2.70E-04 | 0.70 (0.44 – 1.11) | 1.28E-01 | 1.13 (0.83 – 1.53) | 4.51E-01 | ||
| rs2492367 | 0.71 (0.39 – 1.29) | 2.62E-01 | 0.42 (0.28 – 0.61) | 5.61E-06 | 0.76 (0.51 – 1.13) | 1.76E-01 | 1.13 (0.82 – 1.57) | 4.56E-01 | ||
| rs1349282 | 0.82 (0.58 – 1.16) | 2.62E-01 | 0.82 (0.66 – 1.02) | 8.15E-02 | 0.59 (0.46 – 0.77) | 7.47E-05 | 1.12 (0.88 – 1.43) | 3.45E-01 | ||
| rs2418412 | 1.19 (0.87 – 1.64) | 2.77E-01 | 1.52 (1.22 – 1.89) | 1.91E-04 | 1.25 (0.96 – 1.62) | 1.02E-01 | 0.90 (0.72 – 1.12) | 3.43E-01 | ||
| rs7863577 | 0.83 (0.59 – 1.18) | 3.12E-01 | 0.64 (0.44 – 0.93) | 1.82E-02 | 0.82 (0.50 – 1.34) | 4.29E-01 | 1.13 (0.75 – 1.71) | 5.47E-01 | ||
| rs2657940 | 1.18 (0.85 – 1.64) | 3.19E-01 | 1.46 (1.13 – 1.89) | 4.21E-03 | 1.32 (0.97 – 1.80) | 7.41E-02 | 0.86 (0.66 – 1.13) | 2.70E-01 | ||
| rs2265346 | rs10973012 | P, 1 | 0.84 (0.60 – 1.19) | 3.24E-01 | 0.67 (0.46 – 0.96) | 2.93E-02 | 0.77 (0.48 – 1.22) | 2.66E-01 | 1.15 (0.79 – 1.68) | 4.57E-01 |
| rs2263901 | rs2657940 | 1 | 1.17 (0.85 – 1.63) | 3.32E-01 | 1.45 (1.13 – 1.88) | 4.17E-03 | 1.30 (0.96 – 1.77) | 9.54E-02 | 0.86 (0.66 – 1.13) | 2.70E-01 |
| rs17347854 | 0.80 (0.51 – 1.27) | 3.44E-01 | 0.69 (0.51 – 0.93) | 1.44E-02 | 0.58 (0.41 – 0.84) | 3.88E-03 | 1.26 (0.92 – 1.72) | 1.44E-01 | ||
| rs312929 | 0.88 (0.64 – 1.21) | 4.44E-01 | 0.72 (0.58 – 0.91) | 5.06E-03 | 0.79 (0.60 – 1.03) | 8.21E-02 | 1.23 (0.94 – 1.61) | 1.36E-01 | ||
*
case-only data in CARE and WOSCOPS.
†
case-only data in WOSCOPS.