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. 2012 May 30;7(5):e38340. doi: 10.1371/journal.pone.0038340

Table 1. MC contact enriches biological function gene clusters.

OVCAR3-eGFP SKOV3-eGFP
Biological function ID Gene Name Gene Symbol Fold Change relative to the control ID Gene Name Gene Symbol Fold Change relative to the control
Metastasis 221577_x_at Growth Diffentiation Factor 15 GDF15 27.920 206336_at Chemokine (C-X-C motif) ligand 6 CXCL6 15.511
217678_at Solute carrier family 7 anionic amino acid transporter light chain, xc-system), member 11 SLC7A11 15.653 201438_at Collagen alpha-3(VI) chain COL6A3 10.121
202672_s_at Activating transcription factor 3 ATF3 12.425 212942_s_at KIAA1199 KIAA1199 9.958
201010_s_at Thioredoxin interacting protein TXNIP 9.983 216598_s_at Chemokine (C-C motif) ligand 2 CCL2 8.275
212314_at sel-1 suppressor of lin-12-like 3 SEL1L3 5.560 228128_x_at Pregnancy-associated plasma protein A PAPPA 7.330
200953_s_at cyclin D2 CCND2 5.423 205828_at Matrix metalloproteinase-3 MMP3 5.878
210105_s_at FYN oncogene related to SRC, FGR, YES FYN 5.237
201438_at Collagen alpha-3(VI) chain COL6A3 −9.575
211719_x_at Fibronectin 1 FN1 −10.982
Proliferation of cell lines 221577_x_at Growth Diffentiation Factor 15 GDF15 27.920 1556499_s_at Collagen, type I, alpha 1 COL1A1 31.150
217678_at Solute carrier family 7 anionic amino acid transporter light chain, xc-system), member 11 SLC7A11 15.653 202291_s_at Matrix gla protein MGP 16.068
206085_s_at CTH 14.916 216598_s_at Chemokine (C-C motif) ligand 2 CCL2 8.275
202672_s_at Activating transcription factor 3 ATF3 12.425 204051_s_at Secreted frizzled-related protein 4 SFRP4 7.872
201010_s_at thioredoxin interacting protein TXNIP 9.983 228128_x_at Pregnancy-associated plasma protein A PAPPA 7.330
208763_s_at TSC22 domain family, member 3 TSC22D3 9.287 228335_at Claudin-11 CLDN11 6.752
203725_at growth arrest and DNA-damage-inducible, alpha GADD45A 8.742 212667_at Secreted Protein Acidic and Rich in Cysteine SPARC 6.460
203543_s_at Kruppel-like factor 9 KLF9 7.605 205828_at Matrix metalloproteinase-3 MMP3 5.878
203140_at B-cell CLL/lymphoma 6 BCL6 5.544 209821_at Interleukin 33 IL33 5.069
200953_s_at cyclin D2 CCND2 5.423
212501_at CCAAT/enhancer binding protein (C/EBP), beta CEBPB (includes EG:1051) 5.386
210105_s_at FYN oncogene related to SRC, FGR, YES FYN 5.237
202581_at heat shock 70kDa protein 1A/1B HSPA1A/HSPA1B −5.105
1556499_s_at Collagen, type I, alpha 1 COL1A1 −9.175
211719_x_at Fibronectin 1 FN1 −10.982
200665_s_at Secreted Protein Acidic and Rich in Cysteine SPARC −11.110
Cell Death of tumor cell line 221577_x_at Growth Diffentiation Factor 15 GDF15 27.920 216598_s_at Chemokine (C-C motif) ligand 2 CCL2 8.275
205047_s_at asparagie synthetase (glutamine-hydrolyzing) ASNS 23.756 204051_s_at Secreted frizzled-related protein 4 SFRP4 7.872
217678_at Solute carrier family 7 anionic amino acid transporter light chain, xc-system), member 11 SLC7A11 15.653 212667_at Secreted Protein Acidic and Rich in Cysteine SPARC 6.460
202672_s_at Activating transcription factor 3 ATF3 12.425 208998_at Uncoupling Protein 2 UCP2 −5.162
209383_at DNA-damage-inducible transcript 3 DDIT3 9.775
203725_at growth arrest and DNA-damage-inducible, alpha 8.742
202887_s_at DNA-damage-inducible transcript 4 DDIT4 6.046
203140_at B-cell CLL/lymphoma 6 BCL6 5.544
212501_at CCAAT/enhancer binding protein (C/EBP), beta CEBPB (includes EG:1051) 5.386
202581_at heat shock 70kDa protein 1A/1B HSPA1A/HSPA1B −5.105
210338_s_at heat shock 70kDa protein 8 HSPA8 −7.289
211719_x_at Fibronectin 1 FN1 −10.982
200665_s_at Secreted Protein Acidic and Rich in Cysteine SPARC −11.110

Table showing the biological clusters identified by IPA analysis. p-values for the different clusters are: “Metastasis” (NIH:OVCAR3, p = 6.48*10−6; SKOV3, p = 5.42*10−5), “Proliferation of cell lines” (NIH:OVCAR3, p = 4.36.48*10−7; SKOV3, p = 6.79*10−6) and “Cell death of tumor cell line” (NIH:OVCAR3, p = 5.68*10−8; SKOV3, p = 7.62*10−5). These clusters were shared between NIH:OVCAR3-eGFP and SKOV3-eGFP.