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. 2012 May 30;7(5):e38157. doi: 10.1371/journal.pone.0038157

Figure 1. Attenuated clinical severity of EAN in TNF-α KO versus WT mice.

Figure 1

EAN was induced in TNF-α KO mice and WT mice by immunization with P0 peptide 180–199 in combination with FCA. Using a blinded protocol, two examiners evaluated the clinical severity of EAN mice immediately before immunization (day 0 p.i.) and thereafter every two days until day 59 p.i. From day 14 p.i., the clinical signs of TNF-α KO mice were significantly milder than those of the WT controls (Mann-Whitney u-test). Data are presented as mean value ± SD (n = 12 in both groups). * p<0.05, ** p<0.01.