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. 2012 May 30;7(5):e38197. doi: 10.1371/journal.pone.0038197

Figure 5. Effect of combined cardiac aldosterone and hypertension on cardiac miR-208 and Sox6 expression.

Figure 5

(A): scheme of the interplay of miR-208a and -208b on the regulation of Myh7 expression in hypertensive heart, as drawn from literature data. (B-D): quantitative RT-PCR analysis of miR-208a, Sox6 and miR-208b expression in 9 month-old WT, AS, R and AS-R mice and in AS-R eplerenone treated mice (100 mg/Kg/day) for one month. (E): quantitative RT-PCR analysis of Sox6 expression in NMCM stimulated by 10−5 M AngII in the presence or absence of aldosterone (10−9 M or 10−7 M). Abbreviations and symbols as in Figure 1; HT: hypertension; n = 10–14/group.