Table 6. Comparison of the VO2max response to regular exercise between adverse responders and non-adverse responders for each response trait in each study.
| HERITAGE Whites | HERITAGE Blacks | DREW | INFLAME | |||||
| Adverse responders | Non-adverse responders | Adverse responders | Non-adverse responders | Adverse responders | Non-adverse responders | Adverse responders | Non-adverse responders | |
| Δ Fasting insulin | ||||||||
| N subjects | 38 | 411 | 17 | 184 | 36 | 290 | 12 | 58 |
| Δ VO2max (ml/min) | 382 (34) | 399 (10) | 472 (43) | 385 (14) | 76 (22) | 69 (7) | 99 (61) | 226 (28) |
| Δ VO2max (%) | 16.1 (1.4) | 17.0 (0.4) | 20.6 (2.5) | 18.3 (0.8) | 6.0 (1.7) | 5.8 (0.6) | 8.0 (3.4) | 14.5 (1.6) |
| Δ HDL-C | ||||||||
| N subjects | 28 | 443 | 19 | 220 | 87 | 239 | 21 | 49 |
| Δ VO2max (ml/min) | 384 (40) | 400 (10) | 348 (39) | 388 (12) | 68 (14) | 71(8) | 219 (48) | 196 (32) |
| Δ VO2max (%) | 16.2 (1.7) | 17.0 (0.4) | 15.5 (2.3) | 18.4 (0.7) | 5.4 (1.1) | 6.0 (0.7) | 14.2 (2.7) | 12.9 (1.8) |
| Δ Triglycerides | ||||||||
| N subjects | 37 | 434 | 19 | 220 | 51 | 275 | 9 | 61 |
| Δ VO2max (ml/min) | 424 (34) | 397 (10) | 332 (39) | 392 (13) | 72 (18) | 70 (8) | 136 (72) | 213 (28) |
| Δ VO2max (%) | 17.7 (1.4) | 16.9 (0.4) | 16.9 (2.3) | 18.3 (0.7) | 6.1 (1.5) | 5.8 (0.6) | 8.6 (4.0) | 14.0 (1.6) |
| Δ Systolic BP | ||||||||
| N subjects | 28 | 442 | 16 | 220 | 58 | 268 | 11 | 59 |
| Δ VO2max (ml/min) | 348 (40) | 401 (10) | 396 (42) | 386 (12) | 60 (17) | 72 (8) | 140 (65) | 215 (28) |
| Δ VO2max (%) | 14.8 (1.7) | 17.0 (0.4) | 16.7 (2.5) | 18.2 (0.7) | 4.9 (1.4) | 6.1 (0.6) | 7.5 (3.6) | 14.4 (1.6) |
Data expressed as means and standard deviations.
Δ VO2max expressed as the change with exercise training in ml O2 per minute, reported as LS means with age, sex, and baseline VO2max as covariates. Δ VO2max % reported as LS means with age and sex as covariates.
†
p≤0.05 indicates significant difference in VO2max training response between adverse responders and non-adverse responders.