Table IV.

Stability Analysis of Paclitaxel Exposed to PAA and Dried by Lyophobic Precipitation

		HPLC analysis of paclitaxel
Peak identity	R.R.T.	Standard	Sample 1	Sample 2	Sample 2a
			160 μg PAA	160 μg PAA	160 μg PAA30 minutes
		Total %	Total %	Total %	Total %
Related compound B paclitaxel	0.21	0.03	0.03	0.03	0.03
	0.63		0.03
	0.81	0.34	0.33	0.34	0.34
	0.94	0.12	0.12	0.13	0.12
	1	100	100	100	100
	1.22	0.01
	1.42	0.08	0.06	0.06	0.06
	1.44				0.02
	1.65	0.09	0.08	0.11	0.09
	1.93	0.13	0.12	0.21	0.17
	2.75			0.02
Total percent degradation products		0.81	0.78	0.89	0.83

Peak areas reported as percent of paclitaxel peak. Samples 1 and 2 were two distinct samples dried on two separate days; sample 2a was dried in the same batch as sample 2, but included a 30-min incubation with PAA prior to initiating lyophobic precipitation; RRT relative retention time (relative to paclitaxel peak)