Table I.

Plackett–Burman Experimental Design

Formulation	Amount of drug (mg) (X 1)	Amount of polymer (mg) (X 2)	Stirring rate (rpm) (X 3)	Emulsifier (%w/v) (X 4)	O/W ratio (X 5)	Organic solvent (X 6)	Homogenization time (min) (X 7)
1	25	400	1,200	0.4	1:10	CLF	5
2	25	200	1,200	0.2	1:10	DCM	5
3	50	200	600	0.4	1:10	DCM	10
4	50	400	1,200	0.2	1:10	CLF	10
5	50	200	1,200	0.4	1:20	CLF	5
6	25	200	600	0.4	1:10	CLF	10
7	25	200	1,200	0.2	1:20	DCM	10
8	50	400	600	0.2	1:10	DCM	5
9	50	400	1,200	0.4	1:20	DCM	10
10	25	400	600	0.2	1:20	CLF	10
11	25	400	600	0.4	1:20	DCM	5
12	50	200	600	0.2	1:20	CLF	5

CLF chloroform, DCM dichloromethane