Table II.

Observed Particle Sizes, PDI, Drug Loading, and Entrapment Parameters for the 12 Formulations Determined by Photon Correlation Spectroscopy and Destructive RP-HPLC Analysis

Formulation	Particle size (nm)	Polydispersity index (PDI)	Theoretical drug loading (%)	Actual drug loading (%)	Actual PLGA loading (%)	Entrapment efficiency (%)
1	461.3 ± 42.3	0.381 ± 0.021	5.88	4.6 ± 0.13	95.4	78.3 ± 2.15
2	504.1 ± 25.7	0.436 ± 0.012	11.11	8.63 ± 0.36	91.37	77.67 ± 0.55
3	499.2 ± 31.2	0.642 ± 0.011	20.0	17.89 ± 0.23	82.11	89.46 ± 1.14
4	707.1 ± 51.9	0.390 ± 0.004	11.11	10.6 ± 0.19	89.4	95.47 ± 1.75
5	526.5 ± 41.5	0.562 ± 0.027	20.0	16.29 ± 0.27	83.71	81.45 ± 1.37
6	225.4 ± 32.1	0.500 ± 0.029	11.11	10.43 ± 0.11	89.57	93.88 ± 0.97
7	420.5 ± 31.5	0.349 ± 0.007	11.11	6.13 ± 0.28	93.87	55.08 ± 2.49
8	702.2 ± 45.5	0.259 ± 0.022	11.11	9.86 ± 0.10	90.14	84.76 ± 0.87
9	611.3 ± 38.1	0.257 ± 0.022	11.11	8.57 ± 0.13	91.43	77.14 ± 1.13
10	415.7 ± 25.2	0.817 ± 0.072	5.88	4.31 ± 0.22	95.69	73.24 ± 3.77
11	496.4 ± 45.3	0.321 ± 0.009	5.88	3.09 ± 0.20	96.91	52.61 ± 3.33
12	535.6 ± 22.5	0.457 ± 0.005	20.0	18.53 ± 0.15	81.47	92.65 ± 0.77