Table V.
PLS Histogram Distribution from PLS Score Images of the 12 Formulations
| Formulation | Mean score (±SD) | Skew | Number of pixels |
|---|---|---|---|
| 1 | 0.0296 ± 0.030 | 0.06322 | 2,490 |
| 2 | 0.0765 ± 0.0377 | −0.0580 | 2,488 |
| 3 | 0.1451 ± 0.03263 | −0.0020 | 2,492 |
| 4 | 0.1069 ± 0.03283 | −0.5810 | 2,492 |
| 5 | 0.1149 ± 0.0200 | −0.0991 | 2,492 |
| 6 | 0.0833 ± 0.0200 | 0.0062 | 2,490 |
| 7 | 0.05113 ± 0.0238 | −0.00201 | 2,490 |
| 8 | 0.07903 ± 0.03199 | −0.0664 | 2,488 |
| 9 | 0.07676 ± 0.03192 | −0.02008 | 2,495 |
| 10 | 0.03186 ± 0.02487 | 0.1577 | 2,482 |
| 11 | 0.0076 ± 0.03166 | −0.111 | 2,489 |
| 12 | 0.2151 ± 0.0386 | −0.0101 | 2,490 |
Formulation 12 had the highest mean score while formulation 11 had the lowest mean score. The order of the mean score from PLS is in agreement with the order of drug loading determined by RP-HPLC