Table I.
Characteristics of HPMC Powder and Dispersion and NCT-MAS Complex-Loaded Matrix Tablets Prepared Using Different Viscosity Grades of HPMC
| HPMC characteristics | LV-HPMC | MV-HPMC | HV-HPMC |
|---|---|---|---|
| Powders | |||
| Particles sizea (μm) | 106.8 ± 3.1 | 75.7 ± 0.2 | 96.2 ± 1.3 |
| Dispersions | |||
| Viscositya (cP) | 7.80 ± 0.02 | 24.00 ± 0.01 | 52.24 ± 0.01 |
| Tablets | |||
| Thicknessa (mm) | 1.81 ± 0.04 | 1.82 ± 0.03 | 1.83 ± 0.03 |
| Hardnessa (N) | 66.6 ± 8.2 | 100.7 ± 3.5 | 118.4 ± 1.8 |
| Release of whole tabletsa | |||
| n | 0.77 ± 0.05 (R 2 = 0.996) | 1.21 ± 0.06 (R 2 = 0.995) | 0.61 ± 0.05 (R 2 = 0.991) |
| K 0 (% min−1) | 0.21 ± 0.01 (R 2 = 0.939) | 0.55 ± 0.05 (R 2 = 0.992) | 0.11 ± 0.01 (R 2 = 0.939) |
| K H (% min−0.5) | 3.84 ± 0.25 (R 2 = 0.995) | 7.14 ± 0.72 (R 2 = 0.929) | 2.63 ± 0.05 (R 2 = 0.996) |
| Unidirectional releasea | |||
| n | 0.59 ± 0.02 (R 2 = 0.999) | 0.60 ± 0.01 (R 2 = 0.997) | 0.54 ± 0.01 (R 2 = 0.998) |
| K 0 (μg min−1) | 10.57 ± 0.36 (R 2 = 0.973) | 9.54 ± 0.46 (R2 = 0.979) | 6.61 ± 0.15 (R 2 = 0.973) |
| K H (μg min−0.5) | 259.6 ± 9.6 (R 2 = 0.994) | 242.1 ± 11.5 (R 2 = 0.994) | 162.2 ± 4.2 (R 2 = 0.993) |
| Unidirectional permeationa | |||
| K 0 (μg min−1) | 4.66 ± 0.92 (0.969) | 4.33 ± 0.75 (R 2 = 0.990) | 3.96 ± 0.49 (R 2 = 0.997) |
| K H (μg min−0.5) | 122.1 ± 24.2 (0.993) | 117.3 ± 19.4 (R 2 = 0.985) | 109.3 ± 12.3 (R 2 = 0.978) |
| Mucoadhesive propertyb | |||
| F max (mN) | 541.5 ± 173.6 | 486.7 ± 122.3 | 600.3 ± 140.2 |
| W ad (mN mm) | 525.7 ± 87.7 | 436.6 ± 93.3 | 577.5 ± 127.4 |
Particle size of HPMC powder was measured using a laser diffraction particle size analyzer. Of the HPMC dispersion, 2% (w/v) was used for viscosity determination at 32 ± 1°C
aData are the mean ± SD, n = 3
bData are the mean ± SD, n = 5