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A, the occupation-effect relation for MOR fractional occupation was obtained from dose-effect data of tapentadol in the presence of yohimbine. The ED50 for MOR fractional occupation is 0.92 (corresponding to dose 15.3 mg/kg) with 95% CLs (0.86–0.94). B, occupation-effect relation for NAT (obtained with naloxone block) is plotted. This component of tapentadol's action is not evident for NAT fractional occupation less than 0.54.
