Table 2.
System | Mechanism |
---|---|
ER stress | Reduces expression of the proapoptotic transcription factor CHOP/GADD153 [87]. |
Glioblastoma differentiation | Promotes self-renewal through interaction with Bmi1 [81]. |
Death receptor complex | Inhibits apoptotic signaling and caspase activation [83]. |
Chemotherapy | Targeted by death-inducing drugs suggesting an inhibitory role [84]. |
Oncogenic activation | Inhibits apoptotic activation by c-myc [82]. |
Glucose metabolism | Prevents apoptosis through mitochondrial stabilization [82]. |