Table 1.
Characteristics of the 51 SNPs studied in the PON gene cluster.
| SNP | Gene | Functiona | Minor alleleb | Major allele | MAFc |
|---|---|---|---|---|---|
| rs854549 | PON1 | 3′-downstream | A | C | 0.337 |
| rs3735590 | PON1 | 3′-UTR | A | G | 0.060 |
| rs3917577 | PON1 | 3′-UTR | G | A | 0.089 |
| rs854552 | PON1 | 3′-UTR | G | A | 0.265 |
| rs3917551 | PON1 | Intronic | A | G | 0.051 |
| rs3917550 | PON1 | Intronic | A | G | 0.137 |
| rs2269829 | PON1 | Intronic | G | A | 0.278 |
| rs3917542 | PON1 | Intronic | A | G | 0.227 |
| rs3917538 | PON1 | Intronic | A | G | 0.236 |
| rs2299257 | PON1 | Intronic | C | A | 0.391 |
| rs854560 | PON1 | Coding | T | A | 0.360 |
| rs3917498 | PON1 | Intronic | A | C | 0.345 |
| rs28699500 | PON1 | Intronic | G | A | 0.289 |
| rs854561 | PON1 | Intronic | A | G | 0.357 |
| rs854565 | PON1 | Intronic | A | G | 0.294 |
| rs2272365 | PON1 | Intronic | C | A | 0.154 |
| rs854567 | PON1 | Intronic | A | G | 0.185 |
| rs3917490 | PON1 | Intronic | A | G | 0.490 |
| rs2299261 | PON1 | Intronic | G | A | 0.354 |
| rs854568 | PON1 | Intronic | G | A | 0.219 |
| rs2299262 | PON1 | Intronic | A | G | 0.399 |
| rs854569 | PON1 | Intronic | A | C | 0.216 |
| rs2237583 | PON1 | Intronic | A | G | 0.284 |
| rs3917486 | PON1 | Intronic | A | G | 0.054 |
| rs3917481 | PON1 | Intronic | A | G | 0.015 |
| rs2237584 | PON1 | Intronic | A | G | 0.058 |
| rs3917478 | PON1 | Intronic | G | A | 0.118 |
| rs3917476 | PON1 | Intronic | A | C | 0.031 |
| rs854571 | PON1 | 5′-upstream | A | G | 0.289 |
| rs13236941 | PON1 | 5′-upstream | A | G | 0.164 |
| rs13228784 | PON1 | Intronic | G | A | 0.255 |
| rs17883513 | PON1 | Intronic | G | A | 0.032 |
| rs17886762 | PON1 | Intronic | A | G | 0.072 |
| rs17883952 | PON1 | Intronic | A | G | 0.052 |
| rs17884000 | PON3 | Intronic | G | A | 0.202 |
| rs9640632 | PON3 | 3′-UTR | G | A | 0.456 |
| rs468 | PON3 | Intronic | G | A | 0.066 |
| rs11768074 | PON3 | Intronic | A | G | 0.157 |
| rs10487132 | PON3 | Intronic | G | A | 0.390 |
| rs740264 | PON3 | Intronic | C | A | 0.254 |
| rs17884563 | Intergenic | Intergenic | T | A | 0.109 |
| rs17880030 | Intergenic | Intergenic | A | G | 0.199 |
| rs17881071 | Intergenic | Intergenic | A | G | 0.198 |
| rs2375005 | PON2 | Intronic | T | A | 0.462 |
| rs12026 | PON2 | Coding | C | G | 0.240 |
| rs2299264 | PON2 | Intronic | A | G | 0.241 |
| rs7803148 | PON2 | Intronic | A | G | 0.405 |
| rs2158806 | PON2 | Intronic | C | A | 0.237 |
| rs2286233 | PON2 | Intronic | A | T | 0.131 |
| rs10259688 | PON2 | Intronic | G | A | 0.179 |
| rs730365 | PON2 | Intronic | A | G | 0.132 |
Abbreviations: UTR = untranslated region, MAF = minor allele frequency, intergenic = located between two gene regions.
a SNP functional annotation from SNP-Nexus.
b Major and minor allele annotation from the Illumina HumanCVD Bead Chip.
c Minor allele frequencies calculated from the CLEAR study cohort.