Table 2.
Best-fit model from stepwise linear regression predicting PON1 AREase activity.
| Variable | Coefficient (± SE) | Genea | MAFb | t-statisticc | AREase Variation % | P |
|---|---|---|---|---|---|---|
| (Intercept) | 284.09 (±13.99) | — | — | 20.304 | — | < 2.0 × 10−16 |
| PON1C-108T | −24.82 (±2.61) | (PON1) | 0.43 | −9.498 | 14.10% | < 2.0 × 10−16 |
| PON1G-162A | 4.61 (±4.60) | (PON1) | 0.18 | 1.002 | 0.21% | 0.317 |
| PON1Q192R | −22.09 (±4.20) | PON1 | 0.33 | −5.258 | 1.17% | 1.8 × 10−7 |
| PON1M55L | −7.05 (±3.64) | PON1 | 0.42 | −1.94 | 1.01% | 0.053 |
| Age | −1.33 (±0.15) | — | — | −9.014 | 4.29% | < 2.0 × 10−16 |
| Current smoker | −28.25 (±3.63) | — | — | −7.776 | 4.42% | 1.95 × 10−14 |
| rs854567 | −8.19 (±4.77) | (PON1) | A = 0.185 | −1.719 | 2.34% | 0.086 |
| rs2299257 | 12.66 (±3.57) | (PON1) | C = 0.391 | 3.546 | 0.85% | 4.11 × 10−4 |
| rs2237583 | 11.36 (±3.12) | (PON1) | A = 0.284 | 3.645 | 0.5% | 2.82 × 10−4 |
| rs2375005 | −8.32 (±2.56) | (PON2) | T = 0.462 | −3.25 | 0.34% | 0.001 |
| rs3917486 | 14.91 (±4.97) | (PON1) | A = 0.054 | 2.998 | 0.58% | 0.003 |
| rs11768074 | 8.42 (±4.48) | (PON3) | A = 0.157 | 1.878 | 0.26% | 0.061 |
SE = standard error, MAF = minor allele frequency.
aNoncoding SNPs are presented in parentheses, for example, (PON1).
bMinor allele frequencies for the four functional SNPs reported through dbSNP. The remaining minor allele frequencies were calculated via the CLEAR cohort.
c t-statistics and P values were calculated from the coefficients (from all subjects) and standard errors within the best-fit multivariate model by the glm function in R.